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The Philadelphia Phillies (57-43) will host the Boston Red Sox (54-48) at Citizens Bank Park on Tuesday evening, with the game scheduled to get underway at 6:45 p.m. ET. Read on for analysis of the game and the MLB betting lines.
- What? MLB: Philadelphia Phillies vs Boston Red Sox
- Where? Citizens Bank Park, Philadelphia, Pennsylvania
- When? Tuesday, July 22, 2025, 6:45 p.m. ET
Below are the odds from the best MLB Baseball betting sites.
| MLB |  |  |  |
| Boston Red Sox | +165 | +175 | +170 |
| Philadelphia Phillies | -200 | -195 | -195 |
| Boston Red Sox +1.5 | -125 | -125 | -125 |
| Philadelphia Phillies -1.5 | +105 | +105 | +105 |
| Over 8.5 | -110 | -107 | -105 |
| Under 8.5 | -110 | -113 | -115 |
Philadelphia Phillies
The Phillies improved to 57-43 on the season following a narrow 3-2 victory in extra innings on Monday night. After letting a 2-1 advantage slip away in the sixth, Philadelphia came through with the decisive run in the 10th to take the opener. They tallied seven hits as Edmundo Sosa, J.T. Realmuto, and Nick Castellanos each drove in a run. Zack Wheeler started the game, giving up seven hits and two earned runs across six innings. Reliever Tyler Lazar earned the win out of the bullpen.
Philadelphia came into this matchup having dropped two of three to both the Angels and Padres. The club has been alternating wins and losses over its past six games but remains atop the NL East standings. On the season, Phillies pitchers hold a 3.71 ERA, a 1.26 WHIP, and a .245 opponent batting average. Offensively, they’ve posted 457 runs while hitting .254 as a team with a .328 OBP. Kyle Schwarber leads the power department with 32 homers and 74 RBIs. Castellanos has chipped in 12 home runs and 53 RBIs. Southpaw Cristopher Sánchez is expected to start Tuesday’s game. He enters with an 8-2 record, a 2.50 ERA, and a 1.14 WHIP through 115 innings this season.
Boston Red Sox
The Red Sox dropped to 54-48 on the year following a heartbreaking 3-2 loss in 10 innings on Monday night. After evening the score in the sixth, Boston was unable to capitalize in the top of the 10th and ultimately lost the game on a rare catcher’s interference call. The Sox managed eight hits and committed one error in the contest, with Jarren Duran and Trevor Story each driving in a run. Walker Buehler got the start and turned in a solid outing, surrendering just one earned run on six hits across seven innings. Reliever Taylor Hicks was tagged with the loss in extras.
Leading into this series, Boston had dropped two of three to the Cubs following a four-game sweep of Tampa Bay. The team has now lost three of its last four and sits third in the American League East. On the season, Red Sox pitchers have compiled a 3.77 ERA, a 1.30 WHIP, and a .245 opponent batting average. Offensively, they’ve produced 500 runs, boasting a team batting average of .254 and a .324 OBP. Wilyer Abreu has paced the offense with 20 homers and 55 RBIs. Story has contributed 15 home runs and 59 RBIs. Right-hander Richard Fitts is slated to take the mound Tuesday. He carries a 1-3 record with a 4.28 ERA and a 1.22 WHIP through 33.2 innings this season.
Philadelphia Phillies vs Boston Red Sox Prediction
The favored team has come out on top in each of the last 14 games involving the Red Sox. Boston has struggled on the road lately, especially against winning teams from the NL East, dropping six straight matchups in those situations. Additionally, they’ve failed to cover the run line in seven of their last eight night games against NL East opponents following a road defeat.
On the other side, the Phillies have been reliable in similar spots, covering in 13 of their past 15 night games versus American League teams after winning at home. Boston has also had trouble getting off to strong starts, trailing after three innings in 11 of their last 12 road games against winning NL opponents, and behind after five innings in each of their last six road contests against NL East teams with winning records. The Red Sox have also lost the opening frame in six of their last eight games as underdogs facing National League opponents.
Boston entered the All-Star break on a roll and looked poised to rejoin the AL East title conversation, but they’ve since cooled off, dropping three of their last four and managing just three total runs in those defeats. The Red Sox have struggled away from home this season, posting a 22-28 road record. Philadelphia has been strong at Citizens Bank Park with a 32-18 mark. The Phillies have had their own issues with consistency lately, though they’ll send Cristopher Sánchez to the mound. He’s surrendered just one earned run in each of his last five appearances. Boston will counter with Richard Fitts, who’s held opponents to two earned runs or fewer in four of his past five outings, though he typically doesn’t go deep into games.
Each of Boston’s last five night games against teams from the NL East have stayed under the total, continuing a recent trend of low-scoring matchups. Similarly, five of Philadelphia’s last six night games played on the heels of another contest have also finished under the total runs line.
Below are the best offshore sportsbooks for US bettors 2025. You can read our reviews to help determine the best option for your Phillies vs. Red Sox bets.
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