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Left-hander Andrew Abbott will get the start for the Cincinnati Reds on Wednesday as they wrap up a three-game set against the Chicago Cubs at Wrigley Field. The series finale is scheduled to begin at 2:20 p.m. ET. Chicago enters the matchup as the clear favorite, listed at -126 on the moneyline, while Cincinnati sits as a +115 underdog. Oddsmakers have also pegged the Cubs as 1.5-run favorites on the spread, with the over/under for total runs in the game set at 7.5.
- What? MLB: Cincinnati Reds vs. Chicago Cubs
- Where? Wrigley Field, Chicago
- When? Wednesday, August 6, 2025 at 2:20 p.m. ET
Below are the MLB betting lines from the best MLB Baseball betting sites.
| MLB |  |  |  |
| Cincinnati Reds | +115 | +114 | +115 |
| Chicago Cubs | -138 | -126 | -126 |
| Cincinnati Reds +1.5 | -170 | -170 | -170 |
| Chicago Cubs -1.5 | +140 | +149 | +148 |
| Over 7.5 | -115 | -115 | -115 |
| Under 7.5 | -105 | -105 | -105 |
Chicago Cubs
So far this season, the Cubs have found success when labeled as the favorite, winning 52 of 79 such games—good for a 65.8% win rate. They’ve been even more dominant when heavily favored, posting a 15-4 record (78.9%) in games where they entered with moneyline odds of -186 or shorter.
In their previous 10 games, the Cubs have been moneyline favorites in eight and managed to split those contests evenly with a 4-4 record. In that same stretch, just four of their games ended with a combined score surpassing the betting total, despite all 10 matchups having posted over/under lines. Against the spread, Chicago has struggled recently, going just 3-7 in that span.
Individually, the Cubs’ offensive leaders have played key roles throughout the season. Pete Crow-Armstrong has powered the lineup with a team-best 27 home runs, a total that places him seventh among all major league hitters. He’s also top-10 in RBI, sitting ninth overall. Seiya Suzuki has been the Cubs’ most productive run-producer, leading the team with 82 RBIs.
Meanwhile, Nico Hoerner continues to pace the team in batting average, hitting a strong .290 on the year. Across the league, Kyle Tucker remains a notable offensive force—slashing .271 with 21 doubles, four triples, 18 home runs, and 75 walks. He ranks 48th in homers and 45th in RBIs among all MLB hitters.
Cincinnati Reds
The Reds have been no strangers to the underdog role this season, entering 60 games as the lesser-favored side and managing to win 32 of them—a 53.3% success rate.
In their last 10 outings, the Reds were underdogs in half of them and secured three wins across those five contests. However, the offense hasn’t consistently driven totals over the line—only one of their past 10 games has gone over the posted run total. Despite that, Cincinnati has delivered for bettors against the spread, posting a solid 7-3 ATS record over that same stretch.
At the plate, Elly De La Cruz has been Cincinnati’s standout performer, leading the club in batting average (.279), home runs (19), and RBIs (73). Among all MLB hitters, he ranks 38th in long balls and 14th in runs batted in. TJ Friedl has also contributed with a .273 batting average, 16 doubles, two triples, 10 homers, and 54 walks—though his power numbers place him 147th in home runs and 169th in RBIs league-wide.
Spencer Steer has added 13 home runs, along with 15 doubles and two triples, while hitting .239 and drawing 32 walks. Meanwhile, Matt McLain has chipped in with 11 homers, 12 doubles, and 41 walks, despite drawing 32 walks. Meanwhile, Matt McLain has chipped in with 11 homers, 12 doubles, and 41 walks, despite a lower batting average of .223.
Cincinnati Reds vs. Chicago Cubs Prediction And Betting Picks
Chicago looks poised to take the series finale behind a combination of favorable odds and reliable production from its core players. The Cubs have won nearly 66% of the games in which they’ve been favored this season. With Pete Crow-Armstrong providing consistent power and Seiya Suzuki leading the team in RBIs, Chicago’s offense has the tools to support a win, especially against a Reds team that has struggled when priced as significant underdogs. Add in home-field advantage at Wrigley, and the Cubs are in a strong position to edge out Cincinnati.
As for the total, this matchup leans toward the under. Cincinnati’s recent games have largely stayed low-scoring, with only one of their last 10 hitting the over. The Cubs haven’t been much different, staying under in six of their last 10. Even with standout hitters like Elly De La Cruz and Crow-Armstrong in the lineup, both teams have been involved in more tight, pitching-driven contests of late. A projected 4-3 score keeps the game competitive while staying just below the 7.5-run threshold, making the under a strong consideration.
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